Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Trial abstract · §5

SURMOUNT-KOA — citing documents

Every Institute document that draws on this record.

Document identifier
CEI-TR-0028/5
Series
Trial abstract
Version
3.4
Published
19 Mar 2025
Last reviewed
19 Dec 2025
Next review
19 Dec 2027
Identifier
10.71829/cei.trial.28
Certainty
Low
Cycle
2025 Q1
Phase
Phase 3
Status
Reported

§5Citing documents

This page records every Institute document that draws on SURMOUNT-KOA. A trial abstract is a node in the document set rather than a leaf: it is cited by the monographs that use its estimate and by the syntheses that include it, and those citations are listed here so that the flow of an estimate through the document set can be followed in both directions.

§5.1Monograph evidence extracts

Table 7. Monograph evidence extracts that draw on this trial.

CompoundIndicationCertainty there
TirzepatideKnee osteoarthritis with obesityLow

§5.2Evidence syntheses

Table 8. Evidence syntheses that include this trial among their contributing studies.

SynthesisReview typeCertainty
Dual and triple incretin receptor agonists compared with single glucagon-like peptide-1 receptor agonists for…Network meta-analysisModerate
Weight change after discontinuation of an incretin receptor agonistIntervention reviewModerate
Gastrointestinal adverse events with incretin receptor agonistsSafety reviewHigh
Change in lean mass during pharmacologically induced weight reductionScoping reviewLow
Completeness of certificates of analysis in the research-supply channelAnalytical evidence reviewModerate
Counter-ion content and its effect on delivered peptide massAnalytical evidence reviewHigh
Analytical surveys of unregulated peptide supplyAnalytical evidence reviewLow
The consequences of a wholly sponsor-generated evidence baseMethodological reviewModerate
Percentage weight change as a surrogate outcomeMethodological reviewLow
Reconstitution practice and delivered doseAnalytical evidence reviewModerate
Acute pancreatitis with incretin-based therapiesSafety reviewModerate
Bacterial endotoxin in research-supply peptide presentationsAnalytical evidence reviewLow
Dependence of reported purity on the analytical methodAnalytical evidence reviewHigh
In-use stability of reconstituted peptide solutionsAnalytical evidence reviewModerate
Distribution of access to obesity pharmacotherapyMethodological reviewLow
Transitivity in the incretin networkMethodological reviewModerate
Tirzepatide in obesity and overweight in adults: effect on the anchor outcomeIntervention reviewHigh
Tirzepatide in obesity and overweight in adults: tolerability and discontinuationSafety reviewHigh
Tirzepatide in obesity and overweight in adults: durability of effectIntervention reviewHigh

§5.3Other records in the same programme

Table 9. Other records in the SURMOUNT — tirzepatide in obesity.

RecordTypePhaseStatus
SURMOUNT-1Published trial3Reported
SURMOUNT-2Published trial3Reported
SURMOUNT-3Published trial3Reported
SURMOUNT-4Published trial3Reported
SURMOUNT-5Published trial3Reported
SURMOUNT-OSA-1Published trial3Reported
SURMOUNT-OSA-2Published trial3Reported
SURMOUNT-1-OLEProgramme record3Reported
SURMOUNT-2-PKProgramme record1Reported
SURMOUNT-3-REGIONAL-JPProgramme record3Reported
SURMOUNT-4-HEPATIC-IMPProgramme record1Reported
SURMOUNT-OSA-1-OLEProgramme record3Reported
SURMOUNT-OSA-2-BODY-COMPProgramme record3Reported
SURMOUNT-KOA-REGIONAL-JPProgramme record3Reported
SURMOUNT-1-ELDERLYProgramme record3Reported
SURMOUNT-2-RENAL-IMPProgramme record1Reported
SURMOUNT-3-BODY-COMPProgramme record3Reported
SURMOUNT-4-DDIProgramme record1Reported
SURMOUNT-OSA-1-ELDERLYProgramme record3Reported
SURMOUNT-KOA-BODY-COMPProgramme record3Reported
SURMOUNT-2-HEPATIC-IMPProgramme record1Reported
SURMOUNT-3-QOLProgramme record3Reported
SURMOUNT-5-RENAL-IMPProgramme record1Reported
SURMOUNT-2-DDIProgramme record1Reported
SURMOUNT-4-REGIONAL-CNProgramme record3Reported

§5.4Reference

The Institute holds no publication reference for this trial. Where a trial is real and its report has not been obtained, the record says so rather than citing a source it does not hold.

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