Indication assessment · §3
Cutaneous wound healing and tissue repair — trial records
Trial records in the Institute's register bearing on cutaneous wound healing and tissue repair.
§3Trials in this indication
30 trial records in the Institute's register bear on this indication, of which 6 are published trials.
Table 2. Trial records bearing on cutaneous wound healing and tissue repair.
| Record | Compound | Phase | Design | Randomised | Year |
|---|---|---|---|---|---|
| TB4-PH2-DRYEYE | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | 72 | 2015 |
| TB4-PH2-VENOUSULCER | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | 72 | 2013 |
| TB4-PH2-EPIDERMOLYSIS | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | 30 | 2016 |
| LL37-PH1-2-VENOUSULCER | LL-37 | Phase 1/2 | Randomised, double-blind, placebo-controlled | 34 | 2014 |
| GHKCU-TOPICAL-1 | GHK-Cu | Phase 2 | Randomised, double-blind, placebo-controlled | — | 2005 |
| GHKCU-TOPICAL-2 | GHK-Cu | Phase 2 | Randomised, double-blind, placebo-controlled | — | 2007 |
| TB4-PH2-DRYEYE-ELDERLYprogramme record | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | — | 2015 |
| TB4-PH2-VENOUSULCER-OLEprogramme record | Thymosin beta-4 | Phase 2 | Single-arm open-label | — | 2013 |
| TB4-PH2-EPIDERMOLYSIS-REGIONAL-JPprogramme record | Thymosin beta-4 | Phase 3 | Randomised, double-blind, placebo-controlled | — | 2016 |
| LL37-PH1-2-VENOUSULCER-QOLprogramme record | LL-37 | Phase 1/2 | Randomised, double-blind, placebo-controlled | — | 2014 |
| GHKCU-TOPICAL-1-RENAL-IMPprogramme record | GHK-Cu | Phase 1 | Phase 1 ascending dose | — | 2005 |
| GHKCU-TOPICAL-2-HEPATIC-IMPprogramme record | GHK-Cu | Phase 1 | Phase 1 ascending dose | — | 2007 |
| TB4-PH2-DRYEYE-OLEprogramme record | Thymosin beta-4 | Phase 2 | Single-arm open-label | — | 2015 |
| TB4-PH2-VENOUSULCER-ELDERLYprogramme record | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | — | 2013 |
| TB4-PH2-EPIDERMOLYSIS-BODY-COMPprogramme record | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | — | 2016 |
| LL37-PH1-2-VENOUSULCER-REGIONAL-CNprogramme record | LL-37 | Phase 3 | Randomised, double-blind, placebo-controlled | — | 2014 |
| GHKCU-TOPICAL-1-PKprogramme record | GHK-Cu | Phase 1 | Phase 1 ascending dose | — | 2005 |
| GHKCU-TOPICAL-2-DDIprogramme record | GHK-Cu | Phase 1 | Randomised crossover | — | 2007 |
| TB4-PH2-DRYEYE-ADHERENCEprogramme record | Thymosin beta-4 | Phase 2 | Observational | — | 2015 |
| TB4-PH2-VENOUSULCER-BIOMARKERprogramme record | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | — | 2013 |
| TB4-PH2-EPIDERMOLYSIS-QOLprogramme record | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | — | 2016 |
| LL37-PH1-2-VENOUSULCER-REGIONAL-JPprogramme record | LL-37 | Phase 3 | Randomised, double-blind, placebo-controlled | — | 2014 |
| GHKCU-TOPICAL-1-DDIprogramme record | GHK-Cu | Phase 1 | Randomised crossover | — | 2005 |
| GHKCU-TOPICAL-2-PKprogramme record | GHK-Cu | Phase 1 | Phase 1 ascending dose | — | 2007 |
| TB4-PH2-DRYEYE-BIOMARKERprogramme record | Thymosin beta-4 | Phase 2 | Randomised, double-blind, placebo-controlled | — | 2015 |
| TB4-PH2-VENOUSULCER-ADHERENCEprogramme record | Thymosin beta-4 | Phase 2 | Observational | — | 2013 |
| TB4-PH2-EPIDERMOLYSIS-REGIONAL-CNprogramme record | Thymosin beta-4 | Phase 3 | Randomised, double-blind, placebo-controlled | — | 2016 |
| LL37-PH1-2-VENOUSULCER-BODY-COMPprogramme record | LL-37 | Phase 1/2 | Randomised, double-blind, placebo-controlled | — | 2014 |
| GHKCU-TOPICAL-1-HEPATIC-IMPprogramme record | GHK-Cu | Phase 1 | Phase 1 ascending dose | — | 2005 |
| GHKCU-TOPICAL-2-RENAL-IMPprogramme record | GHK-Cu | Phase 1 | Phase 1 ascending dose | — | 2007 |
| This facet in the trial register. | |||||
References cited on this page
References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences 2018;19(7):1987. doi:10.3390/ijms19071987 · PMID 29986520
Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.
Compound Evidence Institute · CEI-IN-23/3 · https://compoundevidence.com/indications/wound-healing/trials/ · retrieved 30 July 2026