Cutaneous wound healing and tissue repair — indication assessment
Restoration of epithelial and dermal integrity following injury, assessed by closure rate, area reduction and scar quality.
§1Assessment
§1.1Definition
Restoration of epithelial and dermal integrity following injury, assessed by closure rate, area reduction and scar quality.
§1.2Anchor and additional outcomes
The Institute designates one anchor outcome per indication so that estimates for different compounds are reported on a common measure. The anchor for this indication is the first outcome below.
- Time to complete closure
- Percentage area reduction
- Scar assessment scale
- Infection rate
§1.3State of the evidence
The Institute assesses 7 compounds in this indication, drawing on 30 trial records and 6 evidence syntheses. No compound is graded above low certainty in this indication, which the Institute records as the principal finding for it.[1,2]
References cited on this page
References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences 2018;19(7):1987. doi:10.3390/ijms19071987 · PMID 29986520
- D’Hondt M, Bracke N, Taevernier L, Gevaert B, Verbeke F, Wynendaele E, De Spiegeleer B. Related impurities in peptide medicines. Journal of Pharmaceutical and Biomedical Analysis 2014;101:2–30. doi:10.1016/j.jpba.2014.06.012 · PMID 25044089
Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.