Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Trial abstract · §5

FLOW — citing documents

Every Institute document that draws on this record.

Document identifier
CEI-TR-0011/5
Series
Trial abstract
Version
3.4
Published
12 Jan 2024
Last reviewed
12 Feb 2025
Next review
12 Feb 2027
Identifier
10.71829/cei.trial.11
Certainty
High
Cycle
2024 Q1
Phase
Phase 3
Status
Reported

§5Citing documents

This page records every Institute document that draws on FLOW. A trial abstract is a node in the document set rather than a leaf: it is cited by the monographs that use its estimate and by the syntheses that include it, and those citations are listed here so that the flow of an estimate through the document set can be followed in both directions.

§5.1Monograph evidence extracts

Table 7. Monograph evidence extracts that draw on this trial.

CompoundIndicationCertainty there
SemaglutideChronic kidney disease in type 2 diabetesHigh

§5.2Evidence syntheses

Table 8. Evidence syntheses that include this trial among their contributing studies.

SynthesisReview typeCertainty
Gastrointestinal adverse events with incretin receptor agonistsSafety reviewHigh
Oral compared with injectable presentations of glucagon-like peptide-1 receptor agonismNetwork meta-analysisModerate
Kidney outcomes with incretin receptor agonists in chronic kidney diseaseIntervention reviewHigh
Completeness of certificates of analysis in the research-supply channelAnalytical evidence reviewModerate
Counter-ion content and its effect on delivered peptide massAnalytical evidence reviewHigh
Analytical surveys of unregulated peptide supplyAnalytical evidence reviewLow
The consequences of a wholly sponsor-generated evidence baseMethodological reviewModerate
The rodent thyroid C-cell signal and its human relevanceSafety reviewLow
Reconstitution practice and delivered doseAnalytical evidence reviewModerate
Acute pancreatitis with incretin-based therapiesSafety reviewModerate
Bacterial endotoxin in research-supply peptide presentationsAnalytical evidence reviewLow
Tirzepatide compared with semaglutide in type 2 diabetesIntervention reviewHigh
Dependence of reported purity on the analytical methodAnalytical evidence reviewHigh
In-use stability of reconstituted peptide solutionsAnalytical evidence reviewModerate
Semaglutide in type 2 diabetes mellitus: effect on the anchor outcomeIntervention reviewHigh
Semaglutide in type 2 diabetes mellitus: tolerability and discontinuationSafety reviewHigh
Semaglutide in type 2 diabetes mellitus: durability of effectIntervention reviewHigh

§5.3Other records in the same programme

Table 9. Other records in the FLOW — semaglutide in chronic kidney disease.

RecordTypePhaseStatus
FLOW-PKProgramme record1Reported
FLOW-RENAL-IMPProgramme record1Reported
FLOW-HEPATIC-IMPProgramme record1Reported

§5.4Reference

The published report or reports the Institute holds for this trial[1].

References cited on this page

References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.

  1. Perkovic V, Tuttle KR, Rossing P, Mahaffey KW, Mann JFE, Bakris G, Baeres FMM, Idorn T, Bosch-Traberg H, Lausvig NL, Pratley R. Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes. New England Journal of Medicine 2024;391(2):109–121. doi:10.1056/NEJMoa2403347 · PMID 38785209

Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.

Nothing published by the Institute is medical advice, a diagnosis, a prescription, a treatment recommendation or a purchasing recommendation. Compounds supplied for research use are not approved for human or veterinary use in any jurisdiction, and a favourable analytical assessment of a supplier is not a statement that any product is safe or effective. The Institute publishes certainty ratings and never recommendations. No telephone number, messaging handle or ordering channel appears anywhere on this site.