Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Trial abstract · §5

ATTAIN-2 — citing documents

Every Institute document that draws on this record.

Document identifier
CEI-TR-0046/5
Series
Trial abstract
Version
2.2
Published
09 Jan 2025
Last reviewed
09 Sep 2025
Next review
09 Sep 2027
Identifier
10.71829/cei.trial.46
Certainty
Not rated
Cycle
2025 Q1
Phase
Phase 3
Status
Reported

§5Citing documents

This page records every Institute document that draws on ATTAIN-2. A trial abstract is a node in the document set rather than a leaf: it is cited by the monographs that use its estimate and by the syntheses that include it, and those citations are listed here so that the flow of an estimate through the document set can be followed in both directions.

§5.1Monograph evidence extracts

Table 7. Monograph evidence extracts that draw on this trial.

CompoundIndicationCertainty there
OrforglipronObesity and overweight in adultsModerate

§5.2Evidence syntheses

Table 8. Evidence syntheses that include this trial among their contributing studies.

SynthesisReview typeCertainty
Gastrointestinal adverse events with incretin receptor agonistsSafety reviewHigh
Oral compared with injectable presentations of glucagon-like peptide-1 receptor agonismNetwork meta-analysisModerate
Completeness of certificates of analysis in the research-supply channelAnalytical evidence reviewModerate
Counter-ion content and its effect on delivered peptide massAnalytical evidence reviewHigh
Analytical surveys of unregulated peptide supplyAnalytical evidence reviewLow
The consequences of a wholly sponsor-generated evidence baseMethodological reviewModerate
Percentage weight change as a surrogate outcomeMethodological reviewLow
Reconstitution practice and delivered doseAnalytical evidence reviewModerate
Bacterial endotoxin in research-supply peptide presentationsAnalytical evidence reviewLow
Dependence of reported purity on the analytical methodAnalytical evidence reviewHigh
In-use stability of reconstituted peptide solutionsAnalytical evidence reviewModerate
Distribution of access to obesity pharmacotherapyMethodological reviewLow
Orforglipron in type 2 diabetes mellitus: effect on the anchor outcomeIntervention reviewModerate
Orforglipron in obesity and overweight in adults: effect on the anchor outcomeIntervention reviewModerate
Orforglipron in type 2 diabetes mellitus: tolerability and discontinuationSafety reviewModerate
Orforglipron in obesity and overweight in adults: tolerability and discontinuationSafety reviewModerate
Orforglipron in type 2 diabetes mellitus: durability of effectIntervention reviewModerate
Orforglipron in obesity and overweight in adults: durability of effectIntervention reviewModerate

§5.3Other records in the same programme

Table 9. Other records in the ATTAIN — orforglipron in obesity.

RecordTypePhaseStatus
ATTAIN-1Published trial3Reported
ATTAIN-1-REGIONAL-JPProgramme record3Reported
ATTAIN-2-ELDERLYProgramme record3Reported
ATTAIN-2-OLEProgramme record3Reported

§5.4Reference

The Institute holds no publication reference for this trial. Where a trial is real and its report has not been obtained, the record says so rather than citing a source it does not hold.

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