Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Monograph series

Repair and regeneration

Peptides supplied for tissue repair, angiogenesis and barrier-function indications.

Monographs in this series

6 documents
  • CEI-MN-030Repair and regenerationUnapproved, research supply4 assessed outcomesversion 1.2

    The proposed mechanism is angiogenic and cytoprotective action through VEGF receptor 2 transactivation and nitric-oxide-pathway modulation, described extensively in rodent models of gastrointestinal, tendon, muscle, nerve and…

    Very low11 May 2024
  • CEI-MN-033Repair and regenerationUnapproved, research supply2 assessed outcomesversion 3.0

    GHK is a naturally occurring tripeptide present in plasma at concentrations that decline with age. Complexed with copper it acts as a physiological copper carrier and, in cultured human fibroblasts, alters expression of a broad…

    Low08 Jan 2026
  • CEI-MN-034Repair and regenerationUnapproved, research supply2 assessed outcomesversion 1.3

    KPV inhibits NF-κB activation and reduces pro-inflammatory cytokine production in epithelial and immune cells. Reported uptake through the intestinal peptide transporter PepT1 provides a plausible route for local action in…

    Very low01 Mar 2024
  • CEI-MN-035Repair and regenerationDiscontinued1 assessed outcomeversion 4.3

    Larazotide antagonises zonulin-mediated tight-junction disassembly, reducing paracellular permeability in intestinal epithelium. The therapeutic hypothesis in coeliac disease was that limiting gluten-peptide translocation across…

    Moderate07 May 2026
  • CEI-MN-031Repair and regenerationUnapproved, research supply3 assessed outcomesversion 4.1

    Thymosin beta-4 is an abundant intracellular actin-sequestering protein with reported extracellular activity in angiogenesis, cell migration and wound repair. TB-500 comprises the actin-binding motif and is supplied on the…

    Very low13 Oct 2025
  • CEI-MN-032Repair and regenerationUnapproved, research supply2 assessed outcomesversion 2.0

    Thymosin beta-4 sequesters monomeric actin and thereby regulates cytoskeletal dynamics, cell migration and wound repair. Extracellular administration in preclinical models promotes angiogenesis, keratinocyte and endothelial…

    Low13 Dec 2023
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