Amylin analogues

Amylin is co-secreted with insulin and acts at the area postrema to promote meal-related satiation, and separately reduces gastric emptying and glucagon secretion. Cagrilintide reproduces this signalling with a pharmacokinetic…

Amylin receptor agonism at the area postrema promoting meal-related satiation, with a formulation and half-life supporting weekly dosing. The therapeutic hypothesis is tolerability advantage rather than efficacy advantage.

Pramlintide reproduces the postprandial actions of endogenous amylin, which is deficient in insulin-deficient diabetes: it slows gastric emptying, suppresses inappropriate postprandial glucagon secretion, and promotes satiation…