Development programme
SUSTAIN — semaglutide in type 2 diabetes
The glycaemic-efficacy and cardiovascular-safety programme for once-weekly semaglutide, including the head-to-head comparison against dulaglutide and the pre-approval cardiovascular outcome trial.
The glycaemic-efficacy and cardiovascular-safety programme for once-weekly semaglutide, including the head-to-head comparison against dulaglutide and the pre-approval cardiovascular outcome trial.
Sponsor class: Manufacturer-sponsored. First record: 2013.
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Records in this programme
17 documents
Table 1. Trial records on this page. The table sorts on any column and filters on the controls above; both operate on the records shown on this page only.
| Record | Compound | Phase | Status | Design | Randomised | Year | Certainty |
|---|---|---|---|---|---|---|---|
| SUSTAIN-1 | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | 388 | 2017 | High |
| SUSTAIN-6 | Semaglutide | Phase 3 | Reported | Event-driven cardiovascular outcome trial | 3,297 | 2016 | High |
| SUSTAIN-7 | Semaglutide | Phase 3 | Reported | Randomised, double-blind, active-controlled | 1,201 | 2018 | High |
| SUSTAIN-1-BODY-COMPprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2017 | Very low |
| SUSTAIN-1-DDIprogramme record | Semaglutide | Phase 1 | Reported | Randomised crossover | — | 2017 | Very low |
| SUSTAIN-1-QOLprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2017 | Very low |
| SUSTAIN-1-REGIONAL-CNprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2017 | Very low |
| SUSTAIN-1-REGIONAL-JPprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2017 | Very low |
| SUSTAIN-6-BODY-COMPprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2016 | Very low |
| SUSTAIN-6-QOLprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2016 | Very low |
| SUSTAIN-6-REGIONAL-CNprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2016 | Very low |
| SUSTAIN-6-REGIONAL-JPprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2016 | Very low |
| SUSTAIN-7-ADHERENCEprogramme record | Semaglutide | Phase 3 | Reported | Observational | — | 2018 | Very low |
| SUSTAIN-7-BIOMARKERprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2018 | Very low |
| SUSTAIN-7-ELDERLYprogramme record | Semaglutide | Phase 3 | Reported | Randomised, double-blind, placebo-controlled | — | 2018 | Very low |
| SUSTAIN-7-OLEprogramme record | Semaglutide | Phase 3 | Reported | Single-arm open-label | — | 2018 | Very low |
| SUSTAIN-7-RENAL-IMPprogramme record | Semaglutide | Phase 1 | Reported | Phase 1 ascending dose | — | 2018 | Very low |