Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Trial register facet

Trial records in type 2 diabetes mellitus

247 records bearing on type 2 diabetes mellitus.

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Records

247 documents · page 1 of 11

Table 1. Trial records on this page. The table sorts on any column and filters on the controls above; both operate on the records shown on this page only.

RecordCompoundPhaseStatusDesignRandomisedYearCertainty
STRIDESemaglutidePhase 3ReportedRandomised, double-blind, placebo-controlled7922025Moderate
SOULSemaglutide, oralPhase 3ReportedEvent-driven cardiovascular outcome trial9,6502025Moderate
SURPASS-CVOTTirzepatidePhase 3ReportedEvent-driven cardiovascular outcome trial13,2992025Moderate
ATTAIN-2OrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Not rated
ACHIEVE-1OrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Not rated
ACHIEVE-2OrforglipronPhase 3ReportedRandomised, double-blind, active-controlled2025Not rated
REDEFINE-2CagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled1,2062025Moderate
ECNO-PH3-CN-T2DEcnoglutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Not rated
SURPASS-CVOT-PKprogramme recordTirzepatidePhase 1ReportedPhase 1 ascending dose2025Very low
ATTAIN-2-ELDERLYprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ACHIEVE-1-REGIONAL-JPprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ACHIEVE-2-ELDERLYprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
REDEFINE-2-OLEprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedSingle-arm open-label2025Very low
SOUL-RENAL-IMPprogramme recordSemaglutide, oralPhase 1ReportedPhase 1 ascending dose2025Very low
STRIDE-QOLprogramme recordSemaglutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ECNO-PH3-CN-T2D-ELDERLYprogramme recordEcnoglutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
SURPASS-CVOT-RENAL-IMPprogramme recordTirzepatidePhase 1ReportedPhase 1 ascending dose2025Very low
ATTAIN-2-OLEprogramme recordOrforglipronPhase 3ReportedSingle-arm open-label2025Very low
ACHIEVE-1-BODY-COMPprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ACHIEVE-2-OLEprogramme recordOrforglipronPhase 3ReportedSingle-arm open-label2025Very low
REDEFINE-2-ELDERLYprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
SOUL-PKprogramme recordSemaglutide, oralPhase 1ReportedPhase 1 ascending dose2025Very low
STRIDE-REGIONAL-CNprogramme recordSemaglutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ECNO-PH3-CN-T2D-OLEprogramme recordEcnoglutidePhase 3ReportedSingle-arm open-label2025Very low

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