Trial abstract
ACHIEVE-2 — structured trial abstract
ACHIEVE-2 — Orforglipron in type 2 diabetes: randomised, double-blind, active-controlled
§1Structured abstract
§1.1Objective
To evaluate Orforglipron in type 2 diabetes mellitus, against the comparator specified in §2, with the primary endpoint stated below.
§1.2Design
- Design
- Randomised, double-blind, active-controlled, parallel-group
- Masking
- Double-blind (participant and investigator)
- Phase
- Phase 3
- Randomised participants
- not recorded by the Institute
- Duration of the primary analysis period
- 52 weeks
- Sponsor class
- Manufacturer-sponsored
- Registry identifier
- not reproduced — see the note in §1.5
§1.3Primary endpoint
Change in glycated haemoglobin from baseline, orforglipron versus an active comparator
§1.4Principal result
The Institute holds no reported primary result for this trial. Where a result exists and the Institute has not obtained it, the record says so rather than leaving the field blank.
§1.5Provenance of this abstract
Table 1. Field-by-field provenance. The Institute records which fields are extracted from a source and which are its own reconstruction, so that a reader can tell the two apart without leaving the page.
| Field | Provenance | Note |
|---|---|---|
| Design, phase, duration, primary endpoint | Extracted | Reproduced from the published report or the registry record. |
| Randomised participants | Not held | Not recorded by the Institute. The field is left empty rather than estimated. |
| Principal result | Not held | No result is reproduced. |
| Centres, countries and baseline characteristics | Reconstructed | Derived by the Institute from the design class and the randomised total. Presented in §2 as an illustrative operational profile and marked as such. These figures are not published characteristics of this trial. |
| Certainty assessment | Institute judgement | The Institute’s own domain-by-domain assessment, with reasoning recorded against each domain in §4. |
| Registry identifier | Not held | The Institute does not reproduce a registry identifier it has not verified and never constructs one. Documents are referenced by the Institute’s own identifier. |
Compound Evidence Institute · CEI-TR-0048 · https://compoundevidence.com/trials/achieve-2/ · retrieved 30 July 2026