Human evidence for BPC-157
What randomised human evidence exists for BPC-157 in any indication?
§1Abstract
§1.1Review question
What randomised human evidence exists for BPC-157 in any indication?
§1.2PICO frame
Table 1. The registered PICO frame. Any change made after protocol registration is recorded in the amendment log at §5 and is identified there as post hoc.
| Element | As registered |
|---|---|
| Population | Human participants of any age in any indication. |
| Intervention | BPC-157 by any route at any dose. |
| Comparator | Any comparator, including none. |
| Outcomes | Any clinical outcome. |
§1.3Method in brief
A structured map of the available evidence for a question where the Institute judges that a quantitative synthesis is not yet supportable. A scoping review states what would have to exist before an intervention review could be attempted. The protocol was registered with the Institute's secretariat before the search was executed. The search was run on 8 August 2025 across 8 sources and is reproduced in full at §2. Screening, extraction and certainty assessment were performed independently by two members of the secretariat with disagreement resolved by a third.
§1.4Conclusion
The Institute conducted a systematic search for randomised controlled trials of BPC-157 in any human population and indication and identified no trial that met inclusion criteria for which a peer-reviewed report or clinical trial registry record was retrievable. The preclinical literature is substantial, methodologically sound within its scope, and consistent in direction of effect across multiple model systems and research groups. Consistency within preclinical literature is not, however, evidence that an effect will transfer to human populations or that claimed mechanisms in animal tissue will operate identically in human physiology. The Institute therefore grades every human claim for BPC-157 as very low certainty and states explicitly that this grade reflects an absence of adequate human evidence rather than evidence of absence of effect. The compound may have beneficial effects; no randomised human trial has tested whether it does.
The conclusion rests on 1 contributing study, listed with their extracted data at §3 and summarised outcome by outcome at §4.
§1.5Limitations
§1.6Consultation
This review was released for public comment before ratification. Draft synthesis: Human evidence for BPC-157 received 4 submissions. Amendments arising are recorded in the amendment log and are traceable to a numbered submission.