Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Methodology|Interests|Funding|Corrections
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Development programme

ESSENCE — semaglutide in steatohepatitis

A two-part trial in metabolic dysfunction-associated steatohepatitis. Part 1 reported histological endpoints; the clinical-outcome part had not reported at the assessment date.

A two-part trial in metabolic dysfunction-associated steatohepatitis. Part 1 reported histological endpoints; the clinical-outcome part had not reported at the assessment date.

Sponsor class: Manufacturer-sponsored. First record: 2021.

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Records in this programme

4 documents

Table 1. Trial records on this page. The table sorts on any column and filters on the controls above; both operate on the records shown on this page only.

RecordCompoundPhaseStatusDesignRandomisedYearCertainty
ESSENCESemaglutidePhase 3ReportedRandomised, double-blind, placebo-controlled1,1972025Moderate
ESSENCE-DDIprogramme recordSemaglutidePhase 1ReportedRandomised crossover—2025Very low
ESSENCE-PKprogramme recordSemaglutidePhase 1ReportedPhase 1 ascending dose—2025Very low
ESSENCE-RENAL-IMPprogramme recordSemaglutidePhase 1ReportedPhase 1 ascending dose—2025Very low
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