Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Trial register facet

Trial records in obesity and overweight in adults

208 records bearing on obesity and overweight in adults.

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Records

208 documents · page 1 of 9

Table 1. Trial records on this page. The table sorts on any column and filters on the controls above; both operate on the records shown on this page only.

RecordCompoundPhaseStatusDesignRandomisedYearCertainty
SURMOUNT-5TirzepatidePhase 3ReportedRandomised, open-label, active-controlled7512025High
SURMOUNT-KOATirzepatidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Low
ATTAIN-1OrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Moderate
ATTAIN-2OrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Not rated
REDEFINE-1CagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled3,4172025Moderate
REDEFINE-2CagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled1,2062025Moderate
GLORY-1MazdutidePhase 3ReportedRandomised, double-blind, placebo-controlled6102025Moderate
ECNO-PH3-CN-OBESITYEcnoglutidePhase 3ReportedRandomised, double-blind, placebo-controlled6642025Low
SURMOUNT-KOA-REGIONAL-JPprogramme recordTirzepatidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ATTAIN-1-REGIONAL-JPprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ATTAIN-2-ELDERLYprogramme recordOrforglipronPhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
REDEFINE-1-ADHERENCEprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedObservational2025Very low
REDEFINE-2-OLEprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedSingle-arm open-label2025Very low
GLORY-1-QOLprogramme recordMazdutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ECNO-PH3-CN-OBESITY-REGIONAL-JPprogramme recordEcnoglutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
SURMOUNT-KOA-BODY-COMPprogramme recordTirzepatidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ATTAIN-2-OLEprogramme recordOrforglipronPhase 3ReportedSingle-arm open-label2025Very low
REDEFINE-2-ELDERLYprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
GLORY-1-REGIONAL-CNprogramme recordMazdutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
ECNO-PH3-CN-OBESITY-BODY-COMPprogramme recordEcnoglutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
SURMOUNT-5-RENAL-IMPprogramme recordTirzepatidePhase 1ReportedPhase 1 ascending dose2025Very low
REDEFINE-1-ELDERLYprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
REDEFINE-2-BIOMARKERprogramme recordCagriSema (cagrilintide with semaglutide)Phase 3ReportedRandomised, double-blind, placebo-controlled2025Very low
GLORY-1-REGIONAL-JPprogramme recordMazdutidePhase 3ReportedRandomised, double-blind, placebo-controlled2025Very low

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