Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Trial register facet

Trial records for Semaglutide, oral

20 records for Semaglutide, oral, of which 4 are published trials.

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Records

20 documents

Table 1. Trial records on this page. The table sorts on any column and filters on the controls above; both operate on the records shown on this page only.

RecordCompoundPhaseStatusDesignRandomisedYearCertainty
SOULSemaglutide, oralPhase 3ReportedEvent-driven cardiovascular outcome trial9,6502025Moderate
SOUL-RENAL-IMPprogramme recordSemaglutide, oralPhase 1ReportedPhase 1 ascending dose2025Very low
SOUL-PKprogramme recordSemaglutide, oralPhase 1ReportedPhase 1 ascending dose2025Very low
SOUL-DDIprogramme recordSemaglutide, oralPhase 1ReportedRandomised crossover2025Very low
SOUL-HEPATIC-IMPprogramme recordSemaglutide, oralPhase 1ReportedPhase 1 ascending dose2025Very low
OASIS-1Semaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled6672023Moderate
OASIS-1-OLEprogramme recordSemaglutide, oralPhase 3ReportedSingle-arm open-label2023Very low
OASIS-1-BIOMARKERprogramme recordSemaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled2023Very low
OASIS-1-ADHERENCEprogramme recordSemaglutide, oralPhase 3ReportedObservational2023Very low
PIONEER-1Semaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled7032019High
PIONEER-6Semaglutide, oralPhase 3ReportedEvent-driven cardiovascular outcome trial3,1832019High
PIONEER-1-REGIONAL-CNprogramme recordSemaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled2019Very low
PIONEER-6-BIOMARKERprogramme recordSemaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled2019Very low
PIONEER-1-QOLprogramme recordSemaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled2019Very low
PIONEER-6-ADHERENCEprogramme recordSemaglutide, oralPhase 3ReportedObservational2019Very low
PIONEER-1-BODY-COMPprogramme recordSemaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled2019Very low
PIONEER-6-OLEprogramme recordSemaglutide, oralPhase 3ReportedSingle-arm open-label2019Very low
PIONEER-1-REGIONAL-JPprogramme recordSemaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled2019Very low
PIONEER-6-ELDERLYprogramme recordSemaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled2019Very low
PIONEER-6-REGIONAL-JPprogramme recordSemaglutide, oralPhase 3ReportedRandomised, double-blind, placebo-controlled2019Very low
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