Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Trial abstract · §3

CAGRI-PH2-DOSEFIND — results

Primary endpoint, absolute and relative effect where derivable, and harms as reported.

Document identifier
CEI-TR-0053/3
Series
Trial abstract
Version
1.0
Published
10 Jan 2023
Last reviewed
10 Nov 2023
Next review
10 Nov 2025
Identifier
10.71829/cei.trial.53
Certainty
Moderate
Cycle
2023 Q1
Phase
Phase 2
Status
Reported

§3Results

§3.1Primary endpoint

Table 3. Primary endpoint as reported.

EndpointResult as reportedCertainty
Percentage change in body weight across ascending cagrilintide dosesDose-dependent change to −10.8 % at 4.5 mg versus −3.0 % with placeboModerate
Reproduced from the published report. Where the report states a confidence interval the Institute reproduces it; where it does not, none is constructed.

§3.2Endpoint hierarchy

Categorical responder proportionsProportion of participants reaching each categorical response threshold, by arm.ThresholdCagrilintideComparator≥ 5 % reduction84.6 %26.9 %≥ 10 % reduction55.9 %4.4 %≥ 15 % reduction22.5 %1.0 %≥ 20 % reduction6.3 %1.0 %
Figure 1. Illustrative. Categorical responder proportions derived by the Institute from the reported mean change under a logistic response model. These are not the published responder proportions for this trial. The figure is published because a mean conceals the distribution of response, and the shape of that distribution is what a reader most often wants and least often gets.

§3.3Harms as reported

Table 5. Adverse events for Cagrilintide from the safety tables the Institute holds for this compound. Where a row names a different trial as its source, the figure is from that trial and not from this one.

EventActive, %Comparator, %Source trial
Nausea36.015.0Phase 2 dose-finding (4.5 mg)
Vomiting15.04.0Phase 2 dose-finding
Constipation18.09.0Phase 2 dose-finding
Injection-site reaction9.02.0Phase 2 dose-finding
Discontinuation for adverse events6.03.0Phase 2 dose-finding
Compound Evidence Institute · CEI-TR-0053/3 · https://compoundevidence.com/trials/cagri-ph2-dosefind/results/ · retrieved 30 July 2026
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