Evidence synthesis · §4
The rodent thyroid C-cell signal and its human relevance — summary of findings
Outcome-by-outcome summary with effect, certainty and the reason for each downgrade.
§4Summary of findings
§4.1Summary of findings
Table 7. Summary of findings for The rodent thyroid C-cell signal and its human relevance.
| Outcome | Participants (studies) | Effect as reported | Certainty | Reason for downgrade |
|---|---|---|---|---|
| Anchor outcome for this review questionThe outcome the Institute designates as anchor for this indication. | 74,597 (24) | Low certainty evidence bears on this question | Low | inconsistency, imprecision |
| Discontinuation for adverse eventsReported as a summary-of-findings row rather than in a tolerability annex, following a public submission. | 66,783 (24) | Reported per contributing trial; see the included-studies table | Low | inconsistency, imprecision |
| Serious adverse eventsEvent counts are low; the estimate is imprecise by construction. | 65,383 (23) | Reported per contributing trial; see the included-studies table | Very low | risk of bias, indirectness, publication bias |
| Any adverse eventAscertained by spontaneous report in the contributing trials. | 73,797 (24) | Reported per contributing trial; see the included-studies table | Very low | inconsistency, publication bias |
| Certainty ratings describe confidence in the effect estimate for the stated outcome. They are not recommendations and do not transfer between outcomes. | ||||
§4.2Forest plot
Study estimatePooled estimate
§4.3Certainty assessment for the anchor outcome
Table 8. Reasoning recorded against each certainty domain for the anchor outcome.
| Domain | Rating | Reasoning |
|---|---|---|
| Risk of bias | No concern | No serious concern identified in this domain. |
| Inconsistency | Serious | Too few contributing studies to assess consistency formally. |
| Indirectness | No concern | No serious concern identified in this domain. |
| Imprecision | Serious | The event count falls below the optimal information size. |
| Publication bias | No concern | No serious concern identified in this domain. |
| Overall: Low certainty. Confidence in the effect estimate is limited. The true effect may be substantially different from the estimate. | ||
Compound Evidence Institute · CEI-ES-021/4 · https://compoundevidence.com/syntheses/thyroid-c-cell-signal/summary-of-findings/ · retrieved 30 July 2026