Document registry — page 25
Every document the Institute has published, 1,621 in total, with its identifier, type, certainty rating and review date.
Documents
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Record of documents ratified in the 2024 Q4 assessment cycle.
22 Dec 2024 -
Randomised, double-blind, placebo-controlled, phase 2 study of BPC-157 in mucosal barrier over not recorded. Primary result: The Institute has identified references to a…
15 Dec 2024 -
In the population defined for growth hormone deficiency and growth-hormone secretagogue pharmacology, what is the effect of CJC-1295 compared with the comparator used in…
Low12 Dec 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of Tirzepatide in sleep apnoea and obesity over 52 weeks. Primary result: Substantial reduction in the…
High11 Dec 2024 -
Consultation on the draft monograph for Survodutide, which the assessment committee released for public comment before ratification. The draft grades the compound's…
10 Dec 2024 -
Persistent reduction in estimated glomerular filtration rate or persistent albuminuria in the context of type 2 diabetes, staged by eGFR and urine albumin-to-creatinine…
10 Dec 2024 -
Randomised, double-blind, placebo-controlled, phase 2 study of Survodutide in obesity over as stated in the parent protocol. The Institute holds no reported primary…
Very low09 Dec 2024 -
In the population defined for hiv-associated lipodystrophy and excess visceral adiposity, what is the incidence of adverse events leading to discontinuation with…
Moderate08 Dec 2024 -
Randomised, double-blind, placebo-controlled, phase 2 study of Survodutide in mash randomising 295 participants over 48 weeks. Primary result: Improvement in 62 % to 83…
Low08 Dec 2024 -
Consultation on the draft of this intervention review, which registers the question: In adults with obesity and moderate to severe obstructive sleep apnoea, what is the…
05 Dec 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of BPC-157 in mucosal barrier over as stated in the parent protocol. The Institute holds no reported primary…
Very low05 Dec 2024 -
Non-selective melanocortin receptor agonist (cyclic heptapeptide). Melanotan-II is a potent non-selective melanocortin receptor agonist. MC1R agonism stimulates eumelanin synthesis in melanocytes, producing…
Very low02 Dec 2024 -
In the population defined for atherosclerotic cardiovascular disease and cardiovascular risk reduction, what is the incidence of adverse events leading to…
High27 Nov 2024 -
Observational study of Semax in cognition over not recorded. Primary result: Registered in the Russian Federation on a national evidence base the Institute has not been…
20 Nov 2024 -
Phase 1 ascending dose, phase 1 study of Epithalon in ageing over as stated in the parent protocol. The Institute holds no reported primary result for this record and…
Very low20 Nov 2024 -
Observational study of Selank in cognition over not recorded. Primary result: As for semax. The Institute records the absence of a retrievable controlled trial.
15 Nov 2024 -
Consultation on the draft monograph for Thymosin alpha-1, which the assessment committee released for public comment before ratification. The draft grades the compound's…
13 Nov 2024 -
Synthesis: Maridebart cafraglutide in obesity and overweight in adults: effect on the anchor outcome
In the population defined for obesity and overweight in adults, what is the effect of Maridebart cafraglutide compared with the comparator used in its contributing…
Low13 Nov 2024 -
Peptides, SARMs, injectables and raw materials. 388 published third-party test reports at the date of assessment.
12 Nov 2024 -
Diagnostic accuracy study of Sermorelin in gh axis over single test. Primary result: Formerly marketed as a diagnostic agent; withdrawn for commercial reasons.
Moderate11 Nov 2024 -
In the population defined for obesity and overweight in adults, is the effect of Orforglipron maintained across the full duration of the contributing trials?
Moderate09 Nov 2024 -
Peptides, oligonucleotides, SARMs, injectable oils and raw materials. 350+ catalogue lines.
09 Nov 2024 -
What is the effect of reconstitution practice on the dose actually delivered from a lyophilised research peptide?
Moderate05 Nov 2024 -
Abnormal regional fat distribution with excess visceral adipose tissue, in the setting of HIV infection and antiretroviral therapy.
05 Nov 2024 -
In the population defined for type 2 diabetes mellitus, what is the effect of Lixisenatide compared with the comparator used in its contributing trials on the anchor…
High01 Nov 2024 -
Phase 1 ascending dose, phase 1 study of Maridebart cafraglutide in obesity over as stated in the parent protocol. The Institute holds no reported primary result for…
Very low28 Oct 2024 -
Observational study of Thymalin in immune modulation over not recorded. Primary result: The Institute has not obtained a retrievable protocol or analysis plan and grades…
26 Oct 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of BPC-157 in mucosal barrier over as stated in the parent protocol. The Institute holds no reported primary…
Very low25 Oct 2024 -
Phase 1 ascending dose, phase 1 study of Gonadorelin in gh axis over as stated in the parent protocol. The Institute holds no reported primary result for this record and…
Very low23 Oct 2024 -
Consultation on the draft of this methodological review, which registers the question: What is known about the direction and magnitude of the difference between…
18 Oct 2024 -
Difficulty initiating or maintaining sleep with daytime consequences, assessed by polysomnography, actigraphy or validated questionnaires.
18 Oct 2024 -
Consultation on the draft monograph for Larazotide acetate, which the assessment committee released for public comment before ratification. The draft grades the…
16 Oct 2024 -
What is the relationship between the indications in which melanocortin receptor agonists have been evaluated and the uses under which they are supplied?
Low16 Oct 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of Semax in cognition over as stated in the parent protocol. The Institute holds no reported primary result…
Very low16 Oct 2024 -
Peptides, SARMs, injectable oils and raw materials. Long-established synthesis operation.
15 Oct 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of Gonadorelin in gh axis over as stated in the parent protocol. The Institute holds no reported primary…
Very low15 Oct 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of Semaglutide in hfpef and type 2 diabetes randomising 616 participants over 52 weeks. Primary result…
Moderate14 Oct 2024 -
Randomised, double-blind, placebo-controlled, phase 1 study of Petrelintide in obesity over as stated in the parent protocol. The Institute holds no reported primary…
Very low13 Oct 2024 -
In adults with heart failure with preserved ejection fraction and obesity, what is the effect of an incretin receptor agonist on symptoms and on heart-failure events?
Moderate11 Oct 2024 -
Consultation on the draft of this network meta-analysis, which registers the question: Does an oral presentation of a glucagon-like peptide-1 receptor agonist achieve an…
10 Oct 2024
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