GHRP-6 — compound monograph
Growth-hormone secretagogue, non-selective ghrelin receptor agonist (hexapeptide). Unapproved, research supply. The Institute assesses 2 outcomes for this compound and grades the strongest at very low certainty.
§1Identification and status
§1.1Nomenclature
- Preferred name
- GHRP-6
- Compound class
- Growth-hormone secretagogue, non-selective ghrelin receptor agonist (hexapeptide)
- Assessment series
- Growth-hormone axis
- Synonyms and codes
- growth hormone releasing peptide-6 · SKF-110679 · His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
- Route as evaluated
- Subcutaneous or intravenous
§1.2Chemistry
Chemical identifiers are reproduced where they are public. Where a structure has not been published the monograph records not disclosed rather than constructing one.[1]
- CAS registry number
- 87616-84-0
- Molecular formula
- C46H56N12O6
- Average mass
- 873.01
- Monoisotopic mass
- 872.44
- ATC classification
- not assigned
§1.3Sequence and structural notes
The prototype synthetic growth-hormone-releasing peptide, from which hexarelin, GHRP-2 and the wider secretagogue class were derived. It is the least selective of the group and the most strongly orexigenic.
§1.4Assessment status
The Institute assesses GHRP-6 across 2 indications and grades the strongest of them at very low certainty. Supplied as a research chemical; no marketing authorisation for the uses under which it is supplied.
Table 1. Assessed outcomes for GHRP-6, ordered by certainty. Each row links to the per-indication evidence extract.
| Indication | Effect as recorded | Certainty | Trials |
|---|---|---|---|
| Growth hormone deficiency and growth-hormone secretagogue pharmacology | Dose-dependent acute growth-hormone release with attenuation on repeated administration | Low | 1 |
| Cutaneous wound healing and tissue repair | No randomised human evidence identified | Very low | 0 |
| Effects are reproduced as the contributing trials reported them. Where a confidence interval is held it appears on the per-indication extract rather than in this summary table. | |||
References cited on this page
References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.
- International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. ICH Q6B Specifications: Test Procedures and Acceptance Criteria for Biotechnological/Biological Products. ICH Harmonised Tripartite Guideline 1999;Step 4 version. identifier not held by the Institute
Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.