Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Indication assessment · §4

Polycystic ovary syndrome — compounds assessed

The 2 compounds the Institute assesses in polycystic ovary syndrome.

Document identifier
CEI-IN-11/4
Series
Indication assessment
Version
2.2
Published
01 Sep 2025
Last reviewed
01 Sep 2025
Next review
01 Sep 2027
Identifier
10.71829/cei.ind.11
Certainty
Not rated
Cycle
2025 Q3
ICD-11
5A80.1
Category
Endocrine

§4Compounds assessed

Compounds the Institute assesses in this indication, with the class of each and its overall certainty. A compound appears here whether or not the evidence supports its use, because recording that a compound has been studied and found wanting is as much part of the assessment as recording that one has not.

  • Endogenous decapeptide, gonadotropin-releasing hormone1 contributing trialfull monograph

    Pulsatile administration by pump induces ovulation in hypothalamic amenorrhoea with reported ovulation rates above 80 % per cycle in selected patients — This application requires a pump delivering pulses every 60 to 90 minutes. It cannot be reproduced by…

    Moderate
  • Endogenous decapeptide, KISS1 receptor agonist2 contributing trialsfull monograph

    Kisspeptin-54 has been used as an oocyte-maturation trigger in assisted reproduction with reported reduction in ovarian hyperstimulation risk compared with human chorionic gonadotropin — The assisted-reproduction work used kisspeptin-54, not the decapeptide…

    Low

References cited on this page

References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.

  1. D’Hondt M, Bracke N, Taevernier L, Gevaert B, Verbeke F, Wynendaele E, De Spiegeleer B. Related impurities in peptide medicines. Journal of Pharmaceutical and Biomedical Analysis 2014;101:2–30. doi:10.1016/j.jpba.2014.06.012 · PMID 25044089

Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.

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