Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Methodology|Interests|Funding|Corrections
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Analytical chemistry

Water content

The mass fraction of a lyophilisate that is water. Substantial for a hygroscopic peptide and a direct subtraction from delivered peptide mass.

Document identifier
CEI-GT-141
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Water content

§1.1Also known as

Residual moisture

§1.2Category

Analytical chemistry — Terms describing the determination of identity, purity, content and quality.

§1.3Related terms

  • Karl Fischer titration — The reference method for water content, based on the stoichiometric reaction of water with iodine and sulfur dioxide. The only water determination the Institute accepts…
  • Mass balance — The sum of peptide content, water content and counter-ion content, which should approach one hundred per cent. A certificate that does not permit a mass balance to be…
Compound Evidence Institute · CEI-GT-141 · https://compoundevidence.com/glossary/water-content/ · retrieved 30 July 2026
Nothing published by the Institute is medical advice, a diagnosis, a prescription, a treatment recommendation or a purchasing recommendation. Compounds supplied for research use are not approved for human or veterinary use in any jurisdiction, and a favourable analytical assessment of a supplier is not a statement that any product is safe or effective. The Institute publishes certainty ratings and never recommendations. No telephone number, messaging handle or ordering channel appears anywhere on this site.