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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Analytical chemistry

Related substances

Impurities structurally related to the target peptide, arising from synthesis or degradation. Reported by name and retention time on a complete certificate and as a single aggregate figure on most.

Document identifier
CEI-GT-148
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Related substances

§1.1Also known as

Impurities

§1.2Category

Analytical chemistry — Terms describing the determination of identity, purity, content and quality.

§1.3Related terms

  • Deletion sequence — An impurity lacking one or more residues, arising from incomplete coupling during synthesis. Often close-eluting and detectable only by mass spectrometry.
  • Deamidation — Conversion of asparagine or glutamine to the corresponding acid, adding one dalton and altering charge. A principal storage-related degradation route for peptides in…
Compound Evidence Institute · CEI-GT-148 · https://compoundevidence.com/glossary/related-substances/ · retrieved 30 July 2026
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