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Document set current to 30 July 2026
Defined term · Analytical chemistry

Deamidation

Conversion of asparagine or glutamine to the corresponding acid, adding one dalton and altering charge. A principal storage-related degradation route for peptides in solution.

Document identifier
CEI-GT-150
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Deamidation

§1.2Category

Analytical chemistry — Terms describing the determination of identity, purity, content and quality.

§1.3Related terms

  • Related substances — Impurities structurally related to the target peptide, arising from synthesis or degradation. Reported by name and retention time on a complete certificate and as a…
  • Isomerisation — Conversion of aspartate to isoaspartate through a succinimide intermediate, producing a species of identical mass and different retention. Undetectable by mass alone.
Compound Evidence Institute · CEI-GT-150 · https://compoundevidence.com/glossary/deamidation/ · retrieved 30 July 2026
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