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Document set current to 30 July 2026
Defined term · Analytical chemistry

Orthogonal method

A second analytical method resting on a different physical principle from the first. Identity confirmed by two orthogonal methods is materially stronger than identity confirmed by one, and is…

Document identifier
CEI-GT-145
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Orthogonal method

§1.2Category

Analytical chemistry — Terms describing the determination of identity, purity, content and quality.

§1.3Related terms

  • Mass spectrometry — Determination of mass-to-charge ratio, used to confirm identity. For a peptide, deconvolution of the multiply charged envelope should return an average mass within a…
  • Identity — Confirmation that the material is the substance claimed. Retention-time correspondence alone is weak evidence of identity; mass-spectrometric confirmation of the…
Compound Evidence Institute · CEI-GT-145 · https://compoundevidence.com/glossary/orthogonal-method/ · retrieved 30 July 2026
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