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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Analytical chemistry

Mass spectrometry

Determination of mass-to-charge ratio, used to confirm identity. For a peptide, deconvolution of the multiply charged envelope should return an average mass within a stated tolerance of the…

Document identifier
CEI-GT-142
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Mass spectrometry

§1.1Also known as

MS ESI-MS

§1.2Category

Analytical chemistry — Terms describing the determination of identity, purity, content and quality.

§1.3Related terms

  • Monoisotopic mass — The mass calculated using the most abundant isotope of each element. Requires high resolving power to determine for a peptide of several kilodaltons, and is not…
  • Orthogonal method — A second analytical method resting on a different physical principle from the first. Identity confirmed by two orthogonal methods is materially stronger than identity…
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