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Document set current to 30 July 2026
Defined term · Pharmacology

Acylation

Attachment of a fatty-acid chain to a peptide, most often to mediate reversible albumin binding and thereby extend half-life. The structural feature underlying weekly dosing in this class.

Document identifier
CEI-GT-124
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Acylation

§1.1Also known as

Lipidation

§1.2Category

Pharmacology — Terms describing how a compound acts and how the body handles it.

§1.3Related terms

  • Plasma protein binding — The fraction of a compound bound to circulating protein and therefore not immediately available to distribute or be eliminated. Reversible albumin binding is the…
  • Half-life — The time for a plasma concentration to fall by half during the terminal elimination phase. Determines dosing interval, time to steady state and the time required for…
Compound Evidence Institute · CEI-GT-124 · https://compoundevidence.com/glossary/acylation/ · retrieved 30 July 2026
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