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Document set current to 30 July 2026
Defined term · Pharmacology

Plasma protein binding

The fraction of a compound bound to circulating protein and therefore not immediately available to distribute or be eliminated. Reversible albumin binding is the mechanism by which several compounds…

Document identifier
CEI-GT-111
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Plasma protein binding

§1.2Category

Pharmacology — Terms describing how a compound acts and how the body handles it.

§1.3Related terms

  • Volume of distribution — The apparent volume into which a compound distributes, computed from dose and plasma concentration. A small value indicates confinement to the circulation, as expected…
  • Half-life — The time for a plasma concentration to fall by half during the terminal elimination phase. Determines dosing interval, time to steady state and the time required for…
Compound Evidence Institute · CEI-GT-111 · https://compoundevidence.com/glossary/plasma-protein-binding/ · retrieved 30 July 2026
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