Draft scoping review: change in lean mass during pharmacologically induced weight reduction
Consultation on the draft scoping review of change in lean mass during pharmacologically induced weight reduction. The review is scoping rather than an intervention review because the contributing studies measure body composition by methods that are not…
§1Consultation and window
§1.1Window
- Opened
- 8 May 2026
- Closed
- 22 June 2026
- Duration
- 45 days
- Status
- Closed — the disposition is published
- Document under consultation
- Synthesis: Change in lean mass during pharmacologically induced weight reduction
- Submissions received
- 7
§1.2Consultation questions
The secretariat put the following questions. A submission was not required to address them and several did not; the questions record what the Institute was uncertain about rather than restricting what a respondent could raise.
- Is the decision to conduct a scoping review rather than an intervention review correctly justified on the face of the document?
- Are the body-composition methods represented in the included studies described in enough detail for a reader to see why they are not pooled?
- Does the review state clearly enough that a change in lean mass measured by dual-energy X-ray absorptiometry is not a measurement of muscle function?
§1.3How a submission is handled
- Every submission is signed. The Institute publishes no anonymous submission.
- Every submission carries a declared interest. A declaration of no interest is itself a declaration and is recorded as one. A declaration is not a disqualification and the Institute has never given a submission less weight on that ground.
- A submission from an employee of a marketing-authorisation holder is identified as an industry submission on its face, following a unanimous consultation on the conflicts policy.
- Every submission receives a secretariat response and a disposition. Submissions that are not accepted remain published in full; the Institute does not remove a submission because it disagrees with it.
- There is no voting, no reputation score, no reply thread and no editing after receipt.
§1.4Outcome
The review was amended before ratification. The distinction between a compartment measurement and a functional measurement is now stated in the abstract, and the conditions under which an intervention review could be attempted are stated as a numbered list rather than in prose.
The disposition table, listing each submission with its disposition and the resulting amendment, is at §3.