Compound monographs in the registry — page 2
51 documents of type compound monograph.
Documents
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Growth-hormone-releasing hormone analogue with albumin-binding drug affinity complex. Both variants are GHRH receptor agonists that increase pulsatile growth-hormone secretion and, downstream, IGF-1. The DAC variant…
Low14 Jul 2024 -
GLP-1 receptor agonist, oral formulation with absorption enhancer. Receptor pharmacology is identical to subcutaneous semaglutide. The distinguishing pharmacology is absorption: SNAC buffers the gastric…
High28 Jun 2024 -
Recombinant insulin-like growth factor 1 analogue. IGF-1 receptor agonism with greatly reduced binding-protein sequestration. The consequence is a sustained, unbuffered IGF-1 receptor signal. Because…
Very low18 Jun 2024 -
Synthetic pentadecapeptide derived from a gastric juice protein sequence. The proposed mechanism is angiogenic and cytoprotective action through VEGF receptor 2 transactivation and nitric-oxide-pathway modulation…
Very low11 May 2024 -
Growth-hormone secretagogue, ghrelin receptor agonist (hexapeptide). Ghrelin receptor agonism producing growth-hormone release. Its approved use is a single-dose provocative diagnostic test, for which the acute…
Low17 Apr 2024 -
Growth-hormone secretagogue, non-selective ghrelin receptor agonist (hexapeptide). Hexarelin is a potent ghrelin receptor agonist producing marked growth-hormone release. Unlike ipamorelin it also stimulates…
Very low10 Mar 2024 -
C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone. KPV inhibits NF-κB activation and reduces pro-inflammatory cytokine production in epithelial and immune cells. Reported uptake through the…
Very low01 Mar 2024 -
GLP-2 receptor agonist. GLP-2 receptor agonism promotes intestinal mucosal growth, increases villus height and crypt depth, slows gastric emptying and reduces intestinal…
Moderate30 Jan 2024 -
Endogenous decapeptide, gonadotropin-releasing hormone. Gonadorelin stimulates pituitary release of luteinising hormone and follicle-stimulating hormone. Its pharmacology is dominated by a pattern…
Moderate18 Jan 2024 -
43-residue actin-sequestering polypeptide. Thymosin beta-4 sequesters monomeric actin and thereby regulates cytoskeletal dynamics, cell migration and wound repair. Extracellular administration…
Low13 Dec 2023 -
Triple GIP, GLP-1 and glucagon receptor agonist (acylated). Retatrutide adds glucagon receptor agonism to the dual incretin mechanism. Glucagon receptor activation increases hepatic fatty-acid oxidation and…
Moderate19 May 2023
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