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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Statistics and inference

Testing hierarchy

A pre-specified order in which endpoints are tested, in which testing stops at the first failure. An endpoint below the point of failure is not confirmatory regardless of its nominal significance.

Document identifier
CEI-GT-084
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Testing hierarchy

§1.1Also known as

Hierarchical testing

§1.2Category

Statistics and inference — Terms describing how effects are estimated and how uncertainty is expressed.

§1.3Related terms

  • Multiplicity — The inflation of false-positive rates that follows from testing many hypotheses. Controlled by a pre-specified testing hierarchy, whose position each reported endpoint…
Compound Evidence Institute · CEI-GT-084 · https://compoundevidence.com/glossary/testing-hierarchy/ · retrieved 30 July 2026
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