Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Methodology|Interests|Funding|Corrections
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Statistics and inference

Optimal information size

The number of participants or events a body of evidence would require to be as informative as an adequately powered single trial. Used by the Institute in assessing imprecision.

Document identifier
CEI-GT-079
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Optimal information size

§1.1Also known as

OIS

§1.2Category

Statistics and inference — Terms describing how effects are estimated and how uncertainty is expressed.

§1.3Related terms

  • Imprecision — A confidence interval wide enough that its ends would support different decisions, or an event count too small to constrain the estimate. Assessed against a decision…
Compound Evidence Institute · CEI-GT-079 · https://compoundevidence.com/glossary/optimal-information-size/ · retrieved 30 July 2026
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