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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Statistics and inference

Heterogeneity

Variation in effect estimates across studies beyond that expected from chance. Quantified imperfectly by the I-squared statistic and assessed by inspection of the estimates and their intervals.

Document identifier
CEI-GT-073
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Heterogeneity

§1.2Category

Statistics and inference — Terms describing how effects are estimated and how uncertainty is expressed.

§1.3Related terms

  • I-squared — The proportion of observed variation across studies attributable to heterogeneity rather than to chance. Does not indicate whether the heterogeneity matters, and takes…
  • Inconsistency — Unexplained variation in effect estimates across contributing studies, beyond what chance would produce. Consistency of direction with variation in magnitude is treated…
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