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Document set current to 30 July 2026
Defined term · Pharmacology

Enzymatic degradation

Breakdown of a peptide by proteases, principally dipeptidyl peptidase-4 for incretins. Resistance is engineered by substitution at the cleavage site.

Document identifier
CEI-GT-127
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Enzymatic degradation

§1.1Also known as

Proteolysis

§1.2Category

Pharmacology — Terms describing how a compound acts and how the body handles it.

§1.3Related terms

  • DPP-4 — Dipeptidyl peptidase-4, the protease that cleaves native glucagon-like peptide-1 within minutes. Every long-acting analogue in this set is protected against it…
Compound Evidence Institute · CEI-GT-127 · https://compoundevidence.com/glossary/enzymatic-degradation/ · retrieved 30 July 2026
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