Defined term · Evidence assessment
Downgrading
The reduction of a certainty rating from its starting level because of a concern in one of five domains: risk of bias, inconsistency, indirectness, imprecision and publication bias. Each downgrade is…
§1Downgrading
§1.2Category
Evidence assessment — Terms describing how the Institute judges and reports the strength of evidence.
§1.3Related terms
- Risk of bias — The extent to which features of a study’s design or conduct could produce an effect estimate that systematically departs from the truth. Assessed at the level of the…
- Indirectness — A mismatch between the population, intervention, comparator or outcome of the contributing studies and those of the question being answered. Also applied where an…
- Imprecision — A confidence interval wide enough that its ends would support different decisions, or an event count too small to constrain the estimate. Assessed against a decision…
- Inconsistency — Unexplained variation in effect estimates across contributing studies, beyond what chance would produce. Consistency of direction with variation in magnitude is treated…
- Publication bias — The risk that the studies available to a review are not a representative sample of the studies conducted, most often because studies with unfavourable results were not…
Compound Evidence Institute · CEI-GT-008 · https://compoundevidence.com/glossary/downgrading/ · retrieved 30 July 2026