Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Evidence assessment

Downgrading

The reduction of a certainty rating from its starting level because of a concern in one of five domains: risk of bias, inconsistency, indirectness, imprecision and publication bias. Each downgrade is…

Document identifier
CEI-GT-008
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Downgrading

§1.2Category

Evidence assessment — Terms describing how the Institute judges and reports the strength of evidence.

§1.3Related terms

  • Risk of bias — The extent to which features of a study’s design or conduct could produce an effect estimate that systematically departs from the truth. Assessed at the level of the…
  • Indirectness — A mismatch between the population, intervention, comparator or outcome of the contributing studies and those of the question being answered. Also applied where an…
  • Imprecision — A confidence interval wide enough that its ends would support different decisions, or an event count too small to constrain the estimate. Assessed against a decision…
  • Inconsistency — Unexplained variation in effect estimates across contributing studies, beyond what chance would produce. Consistency of direction with variation in magnitude is treated…
  • Publication bias — The risk that the studies available to a review are not a representative sample of the studies conducted, most often because studies with unfavourable results were not…
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