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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Trial design and conduct

Dose-finding

A study comparing several doses to characterise the dose–response relationship, usually conducted in phase 2 and usually not powered for a definitive efficacy conclusion at any single dose.

Document identifier
CEI-GT-063
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Dose-finding

§1.2Category

Trial design and conduct — Terms describing how a clinical study is constructed and run.

§1.3Related terms

  • Phase 2 — Exploratory clinical development establishing dose and preliminary efficacy. Phase 2 estimates in selected populations are systematically larger than the confirmatory…
  • Dose–response — The relationship between dose and the magnitude of effect. A monotonic relationship supports causal attribution; a non-monotonic one is reported by the Institute as…
Compound Evidence Institute · CEI-GT-063 · https://compoundevidence.com/glossary/dose-finding/ · retrieved 30 July 2026
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