Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Methodology|Interests|Funding|Corrections
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Trial design and conduct

Data monitoring committee

An independent group with access to unblinded accumulating data, empowered to recommend modification or termination. Its recommendation to stop for efficacy is a source of effect-size inflation.

Document identifier
CEI-GT-056
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Data monitoring committee

§1.1Also known as

DMC DSMB

§1.2Category

Trial design and conduct — Terms describing how a clinical study is constructed and run.

§1.3Related terms

  • Early stopping — Termination of a trial before its planned completion, most often for efficacy at an interim analysis. Trials stopped early for efficacy systematically overestimate…
Compound Evidence Institute · CEI-GT-056 · https://compoundevidence.com/glossary/data-monitoring-committee/ · retrieved 30 July 2026
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