Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Methodology|Interests|Funding|Corrections
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Trial design and conduct

Cardiovascular outcome trial

An event-driven trial with a composite cardiovascular endpoint, conducted for several agents in this class as a regulatory requirement to exclude excess risk. A trial designed to exclude harm is not…

Document identifier
CEI-GT-046
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Cardiovascular outcome trial

§1.1Also known as

CVOT

§1.2Category

Trial design and conduct — Terms describing how a clinical study is constructed and run.

§1.3Related terms

  • Event-driven — A trial that continues until a pre-specified number of endpoint events has accrued rather than for a fixed duration. Follow-up duration is therefore a consequence of the…
  • MACE — Major adverse cardiovascular events. Conventionally a three-point composite of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke; four- and…
Compound Evidence Institute · CEI-GT-046 · https://compoundevidence.com/glossary/cardiovascular-outcome-trial/ · retrieved 30 July 2026
Nothing published by the Institute is medical advice, a diagnosis, a prescription, a treatment recommendation or a purchasing recommendation. Compounds supplied for research use are not approved for human or veterinary use in any jurisdiction, and a favourable analytical assessment of a supplier is not a statement that any product is safe or effective. The Institute publishes certainty ratings and never recommendations. No telephone number, messaging handle or ordering channel appears anywhere on this site.