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Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Defined term · Analytical chemistry

Aggregation

Association of peptide molecules into higher-order species, driven by agitation, freeze–thaw cycling and proximity to the isoelectric point. Not detected by a reverse-phase purity method and requires…

Document identifier
CEI-GT-153
Series
Defined term
Version
1.0
Published
30 Jul 2026
Last reviewed
30 Jul 2026
Certainty
Not rated

§1Aggregation

§1.1Also known as

Fibrillation

§1.2Category

Analytical chemistry — Terms describing the determination of identity, purity, content and quality.

§1.3Related terms

  • Size-exclusion chromatography — Separation by hydrodynamic radius, the standard method for aggregate determination. Reported on no certificate in the Institute’s sampled set.
  • Freeze–thaw — Repeated freezing and thawing of a solution. Concentrates solutes in the shrinking liquid fraction, drives pH excursion as buffer components crystallise differentially…
Compound Evidence Institute · CEI-GT-153 · https://compoundevidence.com/glossary/aggregation/ · retrieved 30 July 2026
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